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December 27, 2008

The rise of the biohacker — Do-it-yourself genetic engineering


Long story short: You don't need a tricked-out lab, oodles of grant money and an army of Ph.Ds anymore if you want to play with DNA — people just like you and me (well, you, anyway) are doing it in their kitchens.

Here's yesterday's Associated Press story by Marcus Wohlsen with the details and tips on how to get started cloning yourself.

    Hobbyists Try Genetic Engineering at Home

    Critics worry amateurs could unleash an environmental or medical disaster

    The Apple computer was invented in a garage. Same with the Google search engine. Now, tinkerers are working at home with the basic building blocks of life itself.

    Using homemade lab equipment and the wealth of scientific knowledge available online, these hobbyists are trying to create new life forms through genetic engineering — a field long dominated by Ph.D.s toiling in university and corporate laboratories.

    In her San Francisco dining room lab, for example, 31-year-old computer programmer Meredith L. Patterson [top] is trying to develop genetically altered yogurt bacteria that will glow green to signal the presence of melamine, the chemical that turned Chinese-made baby formula and pet food deadly.

    "People can really work on projects for the good of humanity while learning about something they want to learn about in the process," she said.

    So far, no major gene-splicing discoveries have come out anybody's kitchen or garage.

    But critics of the movement worry that these amateurs could one day unleash an environmental or medical disaster. Defenders say the future Bill Gates of biotech could be developing a cure for cancer in the garage.

    Many of these amateurs may have studied biology in college but have no advanced degrees and are not earning a living in the biotechnology field. Some proudly call themselves "biohackers" — innovators who push technological boundaries and put the spread of knowledge before profits.

    In Cambridge, Mass., a group called DIYbio is setting up a community lab where the public could use chemicals and lab equipment, including a used freezer, scored for free off Craigslist, that drops to 80 degrees below zero, the temperature needed to keep many kinds of bacteria alive.

    Co-founder Mackenzie Cowell, a 24-year-old who majored in biology in college, said amateurs will probably pursue serious work such as new vaccines and super-efficient biofuels, but they might also try, for example, to use squid genes to create tattoos that glow.

    Cowell said such unfettered creativity could produce important discoveries.

    "We should try to make science more sexy and more fun and more like a game," he said.

    Patterson, the computer programmer, wants to insert the gene for fluorescence into yogurt bacteria, applying techniques developed in the 1970s.

    She learned about genetic engineering by reading scientific papers and getting tips from online forums. She ordered jellyfish DNA for a green fluorescent protein from a biological supply company for less than $100. And she built her own lab equipment, including a gel electrophoresis chamber, or DNA analyzer, which she constructed for less than $25, versus more than $200 for a low-end off-the-shelf model.

    Jim Thomas of ETC Group, a biotechnology watchdog organization, warned that synthetic organisms in the hands of amateurs could escape and cause outbreaks of incurable diseases or unpredictable environmental damage.

    "Once you move to people working in their garage or other informal location, there's no safety process in place," he said.

    Some also fear that terrorists might attempt do-it-yourself genetic engineering. But Patterson said: "A terrorist doesn't need to go to the DIYbio community. They can just enroll in their local community college."


The picture up top accompanied the AP story; its caption: "Meredith L. Patterson, a computer programmer by day, conducts an experiment in the dining room of her San Francisco apartment."

[via Jerry Young]

December 27, 2008 at 04:01 PM | Permalink | Comments (3) | TrackBack

Lampada Poltrona


A classic, designed by the great (and reclusive) 94-year-old Italian architect Luigi Caccia Dominioni for Azucena.

Armchair or bedside light with natural, bordeaux or black leather strap.

Reflector in polished chrome or plated brass.

15.8"L x 3.9"D x 3.5"Ø.


Apply within.

December 27, 2008 at 03:01 PM | Permalink | Comments (0) | TrackBack

'You being an anesthesiologist does not help me much when you blog about the same crap as other bloggers' — Wangas


I couldn't agree more with the comment above, received 40 minutes ago.

File under "You can't please 'em all."

December 27, 2008 at 02:01 PM | Permalink | Comments (10) | TrackBack

What is it?


Answer here this time tomorrow.

December 27, 2008 at 01:01 PM | Permalink | Comments (1) | TrackBack

'Der Lauf der Dinge' (The Way Things Go) — by Peter Fischli and David Weiss

Above, a 4:34 excerpt from their 31-minute 1987 film classic.

Fischli and Weiss's movie opens a new show curated by Vik Muniz at New York's Metropolitan Museum of Art entitled "Artist's Choice + Muniz = Rebus."

If you can't make it to MOMA, the Hirshhorn Museum in Washington, D.C. or Sir Isaac's Loft section of the Franklin Institute in Philadelphia, where the film shows daily for free, you can always try seeing if people will chip in to the tune of $14.99 for the DVD, then hold your own screening.

December 27, 2008 at 12:01 PM | Permalink | Comments (1) | TrackBack

Nail Brush


From the website:


Nail Brush

This beautifully hand-crafted and conceptual item is really for your own personal hygiene.


The nail brush is made in a former school for the blind by a company which employs blind people to produce these extraordinary and functional brush items.

Made in Germany.



[via Alistair Why]

December 27, 2008 at 11:01 AM | Permalink | Comments (0) | TrackBack

Sequenza21.com — 'A contemporary classical music community'


I happened on this site when a member took up last Sunday's post on Gilbert Kaplan's recent encounter with the New York Philharmonic as he led the orchestra (above) in Mahler's Symphony No. 2.

It would appear those who contribute are quite knowledgeable and informed when it comes to music.

December 27, 2008 at 10:01 AM | Permalink | Comments (0) | TrackBack

Ovei Chair


Wrote Jonathan Margolis in his "Technopolis" column in the Financial Times "How To Spend It" magazine, "Four years ago I introduced you to the Oculas, a sort of ovoid garden shed in which you can immerse yourself in computing, digital audio entertainment or just meditation. Now it's been updated in this swisher, hand-crafted version, the Ovei, engineered by the esteemed McClaren Applied Technologies. Whether you want it for playing computer games or merely contemplating, it would make a stunning futuristic addition to your home or office interior...."


But don't take Margolis's word for it: watch the video below

and marvel.

From £50,000 (€56,000; $76,000).


Apply within.


Full disclosure: after reading all about it and looking at the pictures and watching the movie, my immediate reaction was "Oy, vey."*

Maybe that's how it got its name — ya think?


*Inside joke.

December 27, 2008 at 09:01 AM | Permalink | Comments (0) | TrackBack

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