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October 19, 2013

Time to rethink the brain as the sole repository of consciousness?


"Flatworms remember their surroundings, even after being decapitated and growing a new head" — that's the subhead of Arielle Duhaime-Ross's interesting Scientific American article, excerpts from which appear below.

Up top, a flatworm's head.


The flatworms known as planarians are neuroscience darlings. Their centralized brain, complex sensory abilities, and rapid regenerative capacities make these nonparasitic worms ideal for studying the mechanisms that regulate stem cell function, neuronal development, and limb regrowth. To this repertoire, scientists have now added a new trick: these invertebrates can store memories outside their brain and retrieve them after losing their head and growing a new one.

Researchers at Tufts University tested the worms' recall by leveraging a quirk of planarian behavior: worms that recognize a familiar locale will settle in to feed more quickly than planarians that find themselves in a new environment. Such newcomers typically need time to explore their surroundings to ensure their safety before they eat. So the researchers introduced planarians to a textured petri dish and allowed them to get acquainted with their environs. Next they decapitated the worms and waited two weeks for their heads to grow back.

The scientists then jogged the worms' memory by briefly returning them to the dish and feeding them. The idea was to revive the dormant memory from the body through a short exposure to familiar turf.

When the researchers returned the trained flatworms to the same dish, the planarians initiated feeding much more quickly than worms that had gone through the same routine but had not explored the dish prior to decapitation.

The experiment upholds a controversial, decades-old finding by a colorful neuroscientist named James V. McConnell. In the 1950s and 1960s McConnell performed similar tests on planarians — going as far as to feed bits of trained worms to their untrained brethren in an effort to transfer molecules of memory. But some researchers questioned the objectivity of his experiments, many of which were detailed not in mainstream journals but in his own Worm Runner's Digest. The Tufts group aimed to minimize observer bias by using a machine to track and analyze the worms' behavior.

The new research, published in the Journal of Experimental Biology, could have implications for the development of artificial memory and the study of neurodegenerative diseases, which researchers hope to treat by someday replacing damaged brain tissue. "We really don't know what that could do to a patient's personality or memories," Levin says. "Planarians are the model that might finally enable us to start looking at that."


Below, the abstract of the the Journal of Experimental Biology paper.


Planarian flatworms are a popular system for research into the molecular mechanisms that enable these complex organisms to regenerate their entire body, including the brain. Classical data suggest that they may also be capable of long-term memory. Thus, the planarian system may offer the unique opportunity to study brain regeneration and memory in the same animal. To establish a system for the investigation of the dynamics of memory in a regenerating brain, we developed a computerized training and testing paradigm that avoided the many issues that confounded previous, manual attempts to train planaria. We then used this new system to train flatworms in an environmental familiarization protocol. We show that worms exhibit environmental familiarization, and that this memory persists for at least 14 days — long enough for the brain to regenerate. We further show that trained, decapitated planaria exhibit evidence of memory retrieval in a savings paradigm after regenerating a new head. Our work establishes a foundation for objective, high-throughput assays in this molecularly-tractable model system that will shed light on the fundamental interface between body patterning and stored memories. We propose planaria as a key emerging model species for mechanistic investigations of the encoding of specific memories in biological tissues. Moreover, this system is likely to have important implications for the biomedicine of stem cell-derived treatments of degenerative brain disorders in human adults.

October 19, 2013 at 08:01 PM | Permalink | Comments (2) | TrackBack

Mason Jar Bento Box


Say what?


From The Grommet:


BNTO Canning Jar Lunchbox Adaptor — "Perfectly Separated"

Dressing for your salad? Dip for your carrots? Yogurt for your strawberries? Used to be pretty messy to tote these toppings until BNTO came along.

Based on the compartmentalized Japanese bento box, the folks at Cuppow worked up a cool idea for the humble Mason Jar.

A BPA-free adaptor sets right into the top of a 6 oz. Mason Jar — really a jar within a jar — and is a neat and tidy answer to adding liquids to your lunch.

Separate the wet from the dry with BNTO.


$9 (Mason jar, vegetables, and dressings not included — sorry about that, Flautist.]

[via Richard Kashdan]

October 19, 2013 at 04:01 PM | Permalink | Comments (0) | TrackBack

Real-time World Almanac: Pick your favorite statistic and follow it to your heart's content

Screen Shot 2013-10-16 at 4.50.28 PM copy

They're all here.

[via reader Joe Peach who warned me in advance that I might not like the icky ads that appear alongside it more often than not:

Screen Shot 2013-10-19 at 12.26.31 PM

No understatement.]

October 19, 2013 at 12:01 PM | Permalink | Comments (0) | TrackBack

IdeaPaint — "Transforms any surface into a dry erase canvas"

How great is this?

Got kids?

nuf sed

Get some here.

[via reader Jo Woo Bay who added, "I just write straight onto the wall! Painting over takes a few coats I've found out much to my annoyance. This would be so much easier. Genius. Although I did like to think I was alone in my writing-on-the-wall anarchy. Clearly not."]

October 19, 2013 at 08:01 AM | Permalink | Comments (3) | TrackBack

Catme 13/Glass Effect 103: Playing with Gray Cat (through Google Glass)

YouTube caption: "FunFact: Those claws are needle-sharp. That's no exaggeration: just the lightest nip by one of them at the base of my thumb resulted in a pinprick-size hole which yielded a drop of bright red blood. Game over."

October 19, 2013 at 04:01 AM | Permalink | Comments (1) | TrackBack

Tracing Paper (Ghost) Sticky Notes










2.8" x 2.2".


40 for $5.95.

October 19, 2013 at 12:01 AM | Permalink | Comments (1) | TrackBack

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